This chapter presents a comprehensive framework for understanding the experience and clinico-physiological response of human beings to space flight. This is purposely not an exhaustive physiology review, but rather an overview of consistent and predictable changes that are clinically relevant. These changes include outward symptoms and effects on health and performance as well as laboratory values and test results deemed important for understanding the clinical norms associated with space flight. Further physiological details are included in the subsequent system-oriented chapters; interested readers are also referred to the more detailed work in the Handbook of Physiology [1] and the recent text Space Physiology by Buckey [2].
By way of introduction, this chapter offers a brief history of human space flight to provide a context for the current state of knowledge of space medicine.
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Baker, E.S., Barratt, M.R., Wear, M.L. (2008). Human Response to Space Flight. In: Barratt, M.R., Pool, S.L. (eds) Principles of Clinical Medicine for Space Flight. Springer, New York, NY. https://doi.org/10.1007/978-0-387-68164-1_2
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