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Erschienen in: Zeitschrift für Gerontologie und Geriatrie 8/2014

01.12.2014 | Originalien

Intraoperative sRAGE kinetics

A new age-related outcome predictor of cardiac surgery

verfasst von: Prof. Dr. A. Simm, PhD, C. Philipp, I. Friedrich, MD, R.J. Scheubel, MD, H.-S. Hofmann, MD, K.H. Meibodi, MD, A. Sablotzki, MD, R.-E. Silber, MD, J. Börgermann, MD

Erschienen in: Zeitschrift für Gerontologie und Geriatrie | Ausgabe 8/2014

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Abstract

Background

Glycated proteins (advanced glycation endproducts, AGE) in tissue are associated with degenerative diseases. This study evaluated the role of sRAGE (soluble receptor for advanced glycation endproducts), a decoy receptor of AGEs in blood, for the outcome of patients after coronary artery bypass grafting (CABG).

Methods

A total of 90 patients undergoing CABG were analysed in two centres. Perioperative blood samples were collected before surgery up to 1 week postoperatively. sRAGE was measured by ELISA. Patients were subdivided regarding age (< 64 versus > 70 years, 14 % versus 35 % female), euroSCORE (< 3 versus > 4, 14 % versus 29 % female) and sRAGE changes between sternotomy and end of the operation (< 30 % versus > 45 %, 33 % versus 33 % female) and subsequently analysed with respect of postoperative outcome parameters.

Results

Preoperative sRAGE values did not correlate with the outcome of the patients. sRAGE levels increase within 10 min from 1,539 ± 96 to 5,311 ± 187 pg/ml after sternotomy, then returning to baseline levels within 2 days after surgery. Comparing the analysed possible risk factors age, euroSCORE and sRAGE changes, no difference was observed regarding 30-day mortality. Age and the euroSCORE are superior with respect of tachyarrythmia, whereas sRAGE kinetics seems to be superior with respect of prolonged postoperative respiration time/stay in the intensive care unit or catecholamine support.

Conclusion

A prolonged, increased intraoperative sRAGE level is a new outcome predictor for patients undergoing CABG surgery, mutually complementary to the euroSCORE.
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Metadaten
Titel
Intraoperative sRAGE kinetics
A new age-related outcome predictor of cardiac surgery
verfasst von
Prof. Dr. A. Simm, PhD
C. Philipp
I. Friedrich, MD
R.J. Scheubel, MD
H.-S. Hofmann, MD
K.H. Meibodi, MD
A. Sablotzki, MD
R.-E. Silber, MD
J. Börgermann, MD
Publikationsdatum
01.12.2014
Verlag
Springer Berlin Heidelberg
Erschienen in
Zeitschrift für Gerontologie und Geriatrie / Ausgabe 8/2014
Print ISSN: 0948-6704
Elektronische ISSN: 1435-1269
DOI
https://doi.org/10.1007/s00391-013-0523-7

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