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Erschienen in: Zeitschrift für Gerontologie und Geriatrie 7/2013

01.10.2013 | Beiträge zum Themenschwerpunkt

Healthy aging: what can we learn from Caenorhabditis elegans?

Gesundes Altern: Was können wir von Caenorhabditis elegans lernen?

verfasst von: A. Torgovnick, A. Schiavi, S. Maglioni, N. Ventura

Erschienen in: Zeitschrift für Gerontologie und Geriatrie | Ausgabe 7/2013

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Abstract

The microscopic worm Caenorhabditis elegans (C. elegans) is one of the most prominent animal models for aging studies. This is underscored by the fact that most of the genes and interventions that modulate the aging process, such as the insulin/IGF pathway, caloric restriction and mitochondrial signalling, were first identified in this organism. Remarkably, many features of the mammalian aging process are recapitulated in C. elegans: over time, damage to macromolecule accumulates, structural cellular components progressively deteriorate, physiological functions decline, resistance to stress and infections decreases, while morbidity and mortality rates increase. In humans, age represents risk factor number one for most diseases ultimately leading to death in industrialized countries, namely cardiovascular diseases, cancer and neurodegenerative disorders. Genes regulating aging in C. elegans are evolutionarily conserved and their deregulation is often involved in the development of age-associated diseases in humans. It is therefore likely that any intervention that extends C. elegans lifespan will indicate strategies to positively impact on healthy human longevity.
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Metadaten
Titel
Healthy aging: what can we learn from Caenorhabditis elegans?
Gesundes Altern: Was können wir von Caenorhabditis elegans lernen?
verfasst von
A. Torgovnick
A. Schiavi
S. Maglioni
N. Ventura
Publikationsdatum
01.10.2013
Verlag
Springer Berlin Heidelberg
Erschienen in
Zeitschrift für Gerontologie und Geriatrie / Ausgabe 7/2013
Print ISSN: 0948-6704
Elektronische ISSN: 1435-1269
DOI
https://doi.org/10.1007/s00391-013-0533-5