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07.11.2017 | Original contribution | Ausgabe 8/2018

Zeitschrift für Gerontologie und Geriatrie 8/2018

Gender differences in mortality among statin users aged 80 years or more

Zeitschrift:
Zeitschrift für Gerontologie und Geriatrie > Ausgabe 8/2018
Autoren:
MD Dan Justo, MD Mark Tchernichovsky, MD Anjelika Kremer, MD Erel Joffe, MD Shany Sherman, MD Marina Ioffe, MD Haim Mayan

Abstract

Background

Little is known about the prognosis associated with statin therapy and its gender differences in older adults aged ≥80 years.

Objective

To study the mortality and survival associated with statin therapy and their gender differences in older adults aged ≥80 years.

Method

This was a historical prospective study conducted at a tertiary medical center. The medical charts of all older adults aged ≥80 years who had been admitted to a single internal medicine department during 1 year were reviewed. All-cause 3‑year mortality and survival rates following hospital admission in men and in women using statins were investigated.

Results

The final cohort included 216 patients: 122 (56.5%) women, mean age 85.3 ± 3.9 years. Overall, 66 (53.2%) women and 58 (46.8%) men used statins for 3 years or more following hospital admission. During this time 48 (39.3%) women and 48 (51.1%) men died. The all-cause 3‑year mortality rates were significantly lower only in women who had used statins compared with women who had not used statins (24.2% vs. 57.1%; relative risk = 0.2; 95% confidence interval 0.1–0.5; p < 0.0001). The 3‑year cumulative survival rates were significantly higher in women who had used statins as part of primary as well as secondary cardiovascular prevention (p < 0.0001 and p = 0.014, respectively). A Cox regression analysis showed that statin therapy was independently associated with low 3‑year cumulative mortality rates in women (hazard ratio=0.3; 95% confidence interval=0.1–0.6; p = 0.001).

Conclusion

In older adults aged ≥80 years, statin therapy is associated with high 3‑year cumulative survival rates only in women.

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