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2018 | OriginalPaper | Buchkapitel

13. Fetale Programmierung

verfasst von : Evelyn Annegret Huhn, Anke Diemert, Ekkehard Schleußner, Kurt Hecher, Petra Clara Arck

Erschienen in: Die Plazenta

Verlag: Springer Berlin Heidelberg

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Zusammenfassung

Lange Zeit wurde angenommen, dass sich das Risiko für Erkrankungen wie beispielsweise koronare Herzerkrankung (KHK) oder Insulinresistenz aus dem genetischen Potential der Eltern entwickelt und durch Umwelteinflüsse wie ein ungünstiger Lebensstil verstärkt wird. Diese Auffassung wurde in den letzten zwei Jahrzehnten durch das Konzept der fetalen Programmierung komplett überworfen. Das Konzept beinhaltet, dass ein Stimulus oder Insult während einer sensiblen Phase der fetalen Entwicklung bleibende Veränderungen der Struktur, Physiologie und des Metabolismus hervorruft und damit das spätere Risiko für chronische Erkrankungen wie KHK und Insulinresistenz, aber auch für Allergien, eine gestörte Stressantwort u. v. m. im Erwachsenenalter bestimmt. Das Konzept der Fetal Origins of Adult Disease (FOAD) wurde vor über 20 Jahren von dem britischen Epidemiologen David Barker vorgestellt und seitdem intensiv beforscht. Die Forschungsansätze zielen darauf ab, die biologischen Mechanismen zu erkennen, über die ein pränataler Stimulus oder Insult die fetale Entwicklung verändert, die Zeitspanne zwischen vorgeburtlichem Stimulus/Insult und späterer Krankheit zu erfassen und die zahlreichen Faktoren zu identifizieren, die ein Erkrankungsrisiko während der gesamten Lebensspanne mitbeeinflussen

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Nächstes Kapitel Fetale Zellen und zellfreie Nukleinsäuren im maternalen Blut: Genetische und immunologische Aspekte

Alexander N, Rosenlöcher F, Stalder T et al (2012) Impact of antenatal synthetic glucocorticoid exposure on endocrine stress reactivity in term-born children. J Clin Endocrinol Metab 97(10):3538–3544. https://doi.org/10.1210/jc.2012-1970CrossRefPubMed

Atègbo J-M, Grissa O, Yessoufou A et al (2006) Modulation of adipokines and cytokines in gestational diabetes and macrosomia. J Clin Endocrinol Metab 91(10):4137–4143. https://doi.org/10.1210/jc.2006-0980CrossRefPubMed

Barker DJP (2004) The developmental origins of adult disease. J Am Coll Nutr 23(6 Suppl):588S–595SCrossRef

Barker DJ, Bull AR, Osmond C, Simmonds SJ (1990) Fetal and placental size and risk of hypertension in adult life. BMJ 301(6746):259–262CrossRef

Barker DJ, Hales CN, Fall CH, Osmond C, Phipps K, Clark PM (1993) Type 2 (non-insulin-dependent) diabetes mellitus, hypertension and hyperlipidaemia (syndrome X): relation to reduced fetal growth. Diabetologia 36(1):62–67CrossRef

Barker DJP, Larsen G, Osmond C, Thornburg KL, Kajantie E, Eriksson JG (2012) The placental origins of sudden cardiac death. Int J Epidemiol 41(5):1394–1399. https://doi.org/10.1093/ije/dys116CrossRefPubMed

Bergman K, Sarkar P, Glover V, O’Connor TG (2010) Maternal prenatal cortisol and infant cognitive development: moderation by infant-mother attachment. Biol Psychiatry 67(11):1026–1032. https://doi.org/10.1016/j.biopsych.2010.01.002CrossRefPubMedPubMedCentral

Bergvall N, Iliadou A, Tuvemo T, Cnattingius S (2005) Birth characteristics and risk of high systolic blood pressure in early adulthood: socioeconomic factors and familial effects. Epidemiology 16(5):635–640CrossRef

Bouchard L, Hivert M-F, Guay S-P, St-Pierre J, Perron P, Brisson D (2012) Placental adiponectin gene DNA methylation levels are associated with mothers’ blood glucose concentration. Diabetes 61(5):1272–1280. https://doi.org/10.2337/db11-1160CrossRefPubMedPubMedCentral

Braun T, Challis JR, Newnham JP, Sloboda DM (2013) Early-Life glucocorticoid exposure: the hypothalamic-pituitary-adrenal axis, placental function, and long-term disease risk. Endocr Rev. 34(6):885–916. https://doi.org/10.1210/er.2013-1012CrossRefPubMed

Briscoe TA, Rehn AE, Dieni S et al (2004) Cardiovascular and renal disease in the adolescent guinea pig after chronic placental insufficiency. Am J Obstet Gynecol 191(3):847–855. https://doi.org/10.1016/j.ajog.2004.01.050CrossRefPubMed

Buka SL, Tsuang MT, Torrey EF, Klebanoff MA, Bernstein D, Yolken RH (2001) Maternal infections and subsequent psychosis among offspring. Arch Gen Psychiatry 58(11):1032–1037CrossRef

Burton GJ, Fowden AL, Thornburg KL (2016) Placental origins of chronic disease. Physiol Rev 96(4):1509–1565. https://doi.org/10.1152/physrev.00029.2015CrossRefPubMedPubMedCentral

Buss C, Davis EP, Shahbaba B, Pruessner JC, Head K, Sandman CA (2012) Maternal cortisol over the course of pregnancy and subsequent child amygdala and hippocampus volumes and affective problems. Proc Natl Acad Sci U S A 109(20):E1312–1319. https://doi.org/10.1073/pnas.1201295109CrossRefPubMedPubMedCentral

Cannon TD, van Erp TGM, Rosso IM et al (2002) Fetal hypoxia and structural brain abnormalities in schizophrenic patients, their siblings, and controls. Arch Gen Psychiatry 59(1):35–41CrossRef

Capobianco E, Fornes D, Linenberg I, Powell TL, Jansson T, Jawerbaum A (2016) A novel rat model of gestational diabetes induced by intrauterine programming is associated with alterations in placental signaling and fetal overgrowth. Mol Cell Endocrinol 422:221–232. https://doi.org/10.1016/j.mce.2015.12.020CrossRefPubMed

Chen Y-Y, Rosario FJ, Shehab MA, Powell TL, Gupta MB, Jansson T (2015) Increased ubiquitination and reduced plasma membrane trafficking of placental amino acid transporter SNAT-2 in human IUGR. Clin Sci (Lond) 129(12):1131–1141. https://doi.org/10.1042/CS20150511CrossRef

Cupedo T, Nagasawa M, Weijer K, Blom B, Spits H (2005) Development and activation of regulatory T cells in the human fetus. Eur J Immunol 35(2):383–390. https://doi.org/10.1002/eji.200425763CrossRefPubMed

Curhan GC, Chertow GM, Willett WC et al (1996) Birth weight and adult hypertension and obesity in women. Circulation 94(6):1310–1315CrossRef

Davis EP, Waffarn F, Sandman CA (2011) Prenatal treatment with glucocorticoids sensitizes the hpa axis response to stress among full-term infants. Dev Psychobiol 53(2):175–183. https://doi.org/10.1002/dev.20510CrossRefPubMed

Desoye G, Nolan CJ (2016) The fetal glucose steal: an underappreciated phenomenon in diabetic pregnancy. Diabetologia 59(6):1089–1094. https://doi.org/10.1007/s00125-016-3931-6CrossRefPubMedPubMedCentral

Dunn E, Kapoor A, Leen J, Matthews SG (2010) Prenatal synthetic glucocorticoid exposure alters hypothalamic-pituitary-adrenal regulation and pregnancy outcomes in mature female guinea pigs. J Physiol 588(5):887–899. https://doi.org/10.1113/jphysiol.2009.182139CrossRefPubMedPubMedCentral

Duthie L, Reynolds RM (2013) Changes in the maternal hypothalamic-pituitary-adrenal axis in pregnancy and postpartum: influences on maternal and fetal outcomes. Neuroendocrinology 98(2):106–115. https://doi.org/10.1159/000354702CrossRefPubMed

Eyers S, Weatherall M, Jefferies S, Beasley R (2011) Paracetamol in pregnancy and the risk of wheezing in offspring: a systematic review and meta-analysis. Clin Exp Allergy 41(4):482–489. https://doi.org/10.1111/j.1365-2222.2010.03691.xCrossRefPubMed

Forsdahl A (1977) Are poor living conditions in childhood and adolescence an important risk factor for arteriosclerotic heart disease? Br J Prev Soc Med 31(2):91–95PubMedPubMedCentral

Frahm KA, Peffer ME, Zhang JY et al (2016) Research resource: the dexamethasone transcriptome in hypothalamic embryonic neural stem cells. Mol Endocrinol 30(1):144–154. https://doi.org/10.1210/me.2015-1258CrossRefPubMed

Freathy RM, Bennett AJ, Ring SM et al (2009) Type 2 diabetes risk alleles are associated with reduced size at birth. Diabetes 58(6):1428–1433. https://doi.org/10.2337/db08-1739CrossRefPubMedPubMedCentral

Garofano A, Czernichow P, Bréant B (1997) In utero undernutrition impairs rat beta-cell development. Diabetologia 40(10):1231–1234. https://doi.org/10.1007/s001250050812CrossRefPubMed

Gernand AD, Schulze KJ, Stewart CP, West KP, Christian P (2016) Micronutrient deficiencies in pregnancy worldwide: health effects and prevention. Nat Rev Endocrinol 12(5):274–289. https://doi.org/10.1038/nrendo.2016.37CrossRefPubMedPubMedCentral

Gibbs K, Collaco JM, McGrath-Morrow SA (2016) Impact of tobacco smoke and nicotine exposure on lung development. Chest 149(2):552–561. https://doi.org/10.1378/chest.15-1858CrossRefPubMedPubMedCentral

Glover V (2011) Annual research review: prenatal stress and the origins of psychopathology: an evolutionary perspective. J Child Psychol Psychiatry 52(4):356–367. https://doi.org/10.1111/j.1469-7610.2011.02371.xCrossRefPubMed

Godfrey KM, Lillycrop KA, Burdge GC, Gluckman PD, Hanson MA (2007) Epigenetic mechanisms and the mismatch concept of the developmental origins of health and disease. Pediatr Res 61(5 Pt 2):5R–10R. https://doi.org/10.1203/pdr.0b013e318045bedbCrossRefPubMed

Gomez-Roig MD, Mazarico E, Valladares E, Guirado L, Fernandez-Arias M, Vela A (2015) Aortic intima-media thickness and aortic diameter in small for gestational age and growth restricted fetuses. PLoS One 10(5):e0126842. https://doi.org/10.1371/journal.pone.0126842CrossRefPubMedPubMedCentral

Gur C, Diav-Citrin O, Shechtman S, Arnon J, Ornoy A (2004) Pregnancy outcome after first trimester exposure to corticosteroids: a prospective controlled study. Reprod Toxicol 18(1):93–101. https://doi.org/10.1016/j.reprotox.2003.10.007CrossRefPubMed

Hales CN, Barker DJ (2001) The thrifty phenotype hypothesis. Br Med Bull 60:5–20CrossRef

Hartwig IRV, Bruenahl CA, Ramisch K et al (2014) Reduced levels of maternal progesterone during pregnancy increase the risk for allergic airway diseases in females only. J Mol Med (Berl) 92(10):1093–1104. https://doi.org/10.1007/s00109-014-1167-9CrossRef

Hewitt DP, Mark PJ, Waddell BJ (2006) Glucocorticoids prevent the normal increase in placental vascular endothelial growth factor expression and placental vascularity during late pregnancy in the rat. Endocrinology 147(12):5568–5574. https://doi.org/10.1210/en.2006-0825CrossRefPubMed

Horvath A, Koletzko B, Szajewska H (2007) Effect of supplementation of women in high-risk pregnancies with long-chain polyunsaturated fatty acids on pregnancy outcomes and growth measures at birth: a meta-analysis of randomized controlled trials. Br J Nutr 98(2):253–259. https://doi.org/10.1017/S0007114507709078CrossRefPubMed

Jansson T, Aye ILMH, Goberdhan DCI (2012) The emerging role of mTORC1 signaling in placental nutrient-sensing. Placenta 33 (Suppl 2): e23–29. https://doi.org/10.1016/j.placenta.2012.05.010CrossRef

Jaquet D, Gaboriau A, Czernichow P, Levy-Marchal C (2000) Insulin resistance early in adulthood in subjects born with intrauterine growth retardation. J Clin Endocrinol Metab 85(4):1401–1406. https://doi.org/10.1210/jcem.85.4.6544CrossRefPubMed

Jensen CB, Martin-Gronert MS, Storgaard H, Madsbad S, Vaag A, Ozanne SE (2008) Altered PI3-kinase/Akt signalling in skeletal muscle of young men with low birth weight. Blagosklonny M V., ed. PLoS One 3(11):e3738. https://doi.org/10.1371/journal.pone.0003738CrossRefPubMedPubMedCentral

Jimenez-Chillaron JC, Isganaitis E, Charalambous M et al (2009) Intergenerational transmission of glucose intolerance and obesity by in utero undernutrition in mice. Diabetes 58(2):460–468. https://doi.org/10.2337/db08-0490CrossRefPubMedPubMedCentral

Kapoor A, Petropoulos S, Matthews SG (2008) Fetal programming of hypothalamic–pituitary–adrenal (HPA) axis function and behavior by synthetic glucocorticoids. Brain Res Rev 57(2):586–595. https://doi.org/10.1016/j.brainresrev.2007.06.013CrossRefPubMed

Keller G, Zimmer G, Mall G, Ritz E, Amann K (2003) Nephron number in patients with primary hypertension. N Engl J Med 348(2):101–108. https://doi.org/10.1056/NEJMoa020549CrossRefPubMed

Khashan AS, Abel KM, McNamee R et al (2008) Higher risk of offspring schizophrenia following antenatal maternal exposure to severe adverse life events. Arch Gen Psychiatry 65(2):146–152. https://doi.org/10.1001/archgenpsychiatry.2007.20CrossRefPubMed

Langley-Evans SC (1997) Hypertension induced by foetal exposure to a maternal low-protein diet, in the rat, is prevented by pharmacological blockade of maternal glucocorticoid synthesis. J Hypertens 15(5):537–544CrossRef

Lassarre C, Hardouin S, Daffos F, Forestier F, Frankenne F, Binoux M (1991) Serum insulin-like growth factors and insulin-like growth factor binding proteins in the human fetus. Relationships with growth in normal subjects and in subjects with intrauterine growth retardation. Pediatr Res 29(3):219–225. https://doi.org/10.1203/00006450-199103000-00001CrossRefPubMed

Leeson CP, Kattenhorn M, Morley R, Lucas A, Deanfield JE (2001) Impact of low birth weight and cardiovascular risk factors on endothelial function in early adult life. Circulation 103(9):1264–1268CrossRef

Lesage J, Blondeau B, Grino M, Bréant B, Dupouy JP (2001) Maternal undernutrition during late gestation induces fetal overexposure to glucocorticoids and intrauterine growth retardation, and disturbs the hypothalamo-pituitary adrenal axis in the newborn rat. Endocrinology 142(5):1692–1702. https://doi.org/10.1210/endo.142.5.8139CrossRefPubMed

McDaniell R, Lee B-K, Song L et al (2010) Heritable individual-specific and allele-specific chromatin signatures in humans. Science 328(5975):235–239. https://doi.org/10.1126/science.1184655CrossRefPubMedPubMedCentral

Mina TH, Räikkönen K, Riley SC, Norman JE, Reynolds RM (2015) Maternal distress associates with placental genes regulating fetal glucocorticoid exposure and IGF2: role of obesity and sex. Psychoneuroendocrinology 59:112–122. https://doi.org/10.1016/j.psyneuen.2015.05.004CrossRefPubMed

Muramatsu-Kato K, Itoh H, Kohmura-Kobayashi Y et al (2015) Undernourishment in utero primes hepatic steatosis in adult mice offspring on an obesogenic diet; involvement of endoplasmic reticulum stress. Sci Rep 5:16867. https://doi.org/10.1038/srep16867CrossRefPubMedPubMedCentral

Mutius E von, Vercelli D (2010) Farm living: effects on childhood asthma and allergy. Nat Rev Immunol 10(12):861–868. https://doi.org/10.1038/nri2871CrossRef

Nilsson PM, Ostergren PO, Nyberg P, Söderström M, Allebeck P (1997) Low birth weight is associated with elevated systolic blood pressure in adolescence: a prospective study of a birth cohort of 149378 Swedish boys. J Hypertens 15(12 Pt 2):1627–1631CrossRef

Nobili V, Marcellini M, Marchesini G et al (2007) Intrauterine growth retardation, insulin resistance, and nonalcoholic fatty liver disease in children. Diabetes Care 30(10):2638–2640. https://doi.org/10.2337/dc07-0281CrossRefPubMed

Non AL, Binder AM, Barault L, Rancourt RC, Kubzansky LD, Michels KB (2012) DNA methylation of stress-related genes and LINE-1 repetitive elements across the healthy human placenta. Placenta 33(3):183–187. https://doi.org/10.1016/j.placenta.2011.12.013CrossRefPubMedPubMedCentral

Okosun IS, Liao Y, Rotimi CN, Dever GE, Cooper RS (2000) Impact of birth weight on ethnic variations in subcutaneous and central adiposity in American children aged 5–11 years. A study from the third National health and nutrition examination survey. Int J Obes Relat Metab Disord 24(4):479–484CrossRef

Oliver MH, Harding JE, Breier BH, Evans PC, Gluckman PD (1992) The nutritional regulation of circulating placental lactogen in fetal sheep. Pediatr Res 31(5):520–523. https://doi.org/10.1203/00006450-199205000-00023CrossRefPubMed

Osmond C, Barker DJ, Winter PD, Fall CH, Simmonds SJ (1993) Early growth and death from cardiovascular disease in women. BMJ 307(6918):1519–1524CrossRef

Ozanne SE, Nave BT, Wang CL, Shepherd PR, Prins J, Smith GD (1997) Poor fetal nutrition causes long-term changes in expression of insulin signaling components in adipocytes. Am J Physiol 273(1 Pt 1):E46–51PubMed

Ozanne SE, Dorling MW, Wang CL, Petry CJ (2000) Depot-specific effects of early growth retardation on adipocyte insulin action. Horm Metab Res 32(2):71–75. https://doi.org/10.1055/s-2007-978592CrossRefPubMed

Ozanne SE, Dorling MW, Wang CL, Nave BT (2001) Impaired PI 3-kinase activation in adipocytes from early growth-restricted male rats. Am J Physiol Endocrinol Metab 280(3):E534–539CrossRef

Ozanne SE, Olsen GS, Hansen LL et al (2003) Early growth restriction leads to down regulation of protein kinase C zeta and insulin resistance in skeletal muscle. J Endocrinol 177(2):235–241CrossRef

Painter RC, Osmond C, Gluckman P, Hanson M, Phillips DIW, Roseboom TJ (2008) Transgenerational effects of prenatal exposure to the Dutch famine on neonatal adiposity and health in later life. BJOG 115(10):1243–1249. https://doi.org/10.1111/j.1471-0528.2008.01822.xCrossRefPubMed

Palmer E, Naeher D (2009) Affinity threshold for thymic selection through a T-cell receptor-co-receptor zipper. Nat Rev Immunol 9(3):207–213. https://doi.org/10.1038/nri2469CrossRefPubMed

Payne JA, Alexander BT, Khalil RA (2004) Decreased Endothelium-Dependent NO-cGMP vascular relaxation and hypertension in growth-restricted rats on a high-salt diet. Hypertension 43(2):420–427. https://doi.org/10.1161/01.HYP.0000111832.47667.13CrossRefPubMed

Peterside IE, Selak MA, Simmons RA (2003) Impaired oxidative phosphorylation in hepatic mitochondria in growth-retarded rats. Am J Physiol – Endocrinol Metab 285(6):E1258–E1266. https://doi.org/10.1152/ajpendo.00437.2002CrossRefPubMed

Pincus M, Keil T, Rücke M et al (2010) Fetal origin of atopic dermatitis. J Allergy Clin Immunol 125(1): 273–275.e4. https://doi.org/10.1016/j.jaci.2009.10.057CrossRef

Qiu A, Rifkin-Graboi A, Chen H et al (2013) Maternal anxiety and infants’ hippocampal development: timing matters. Transl Psychiatry 3(9):e306. https://doi.org/10.1038/tp.2013.79CrossRefPubMedPubMedCentral

Qiu A, Anh TT, Li Y et al (2015) Prenatal maternal depression alters amygdala functional connectivity in 6-month-old infants. Transl Psychiatry 5(2):e508. https://doi.org/10.1038/tp.2015.3CrossRefPubMedPubMedCentral

Ravelli GP, Stein ZA, Susser MW (1976) Obesity in young men after famine exposure in utero and early infancy. N Engl J Med 295(7):349–353. https://doi.org/10.1056/NEJM197608122950701CrossRefPubMed

Raychaudhuri N, Raychaudhuri S, Thamotharan M, Devaskar SU (2008) Histone code modifications repress glucose transporter 4 expression in the intrauterine growth-restricted offspring. J Biol Chem 283(20):13611–13626. https://doi.org/10.1074/jbc.M800128200CrossRefPubMedPubMedCentral

Rifkin-Graboi A, Bai J, Chen H et al (2013) Prenatal maternal depression associates with microstructure of right amygdala in neonates at birth. Biol Psychiatry 74(11):837–844. https://doi.org/10.1016/j.biopsych.2013.06.019CrossRefPubMed

Rosario FJ, Powell TL, Jansson T (2016) Mechanistic target of rapamycin (mTOR) regulates trophoblast folate uptake by modulating the cell surface expression of FR-α and the RFC. Sci Rep 6:31705. https://doi.org/10.1038/srep31705CrossRefPubMedPubMedCentral

Roseboom TJ, van der Meulen JH, Osmond C, Barker DJ, Ravelli AC, Bleker OP (2000) Plasma lipid profiles in adults after prenatal exposure to the Dutch famine. Am J Clin Nutr 72(5):1101–1106CrossRef

Sandman CA, Buss C, Head K, Davis EP (2015) Fetal exposure to maternal depressive symptoms is associated with cortical thickness in late childhood. Biol Psychiatry 77(4):324–334. https://doi.org/10.1016/j.biopsych.2014.06.025CrossRefPubMed

Scholtens S, Postma DS, Moffatt MF et al (2014) Novel childhood asthma genes interact with in utero and early-life tobacco smoke exposure. J Allergy Clin Immunol 133(3):885–888. https://doi.org/10.1016/j.jaci.2013.08.049CrossRefPubMedPubMedCentral

Schwitzgebel VM, Somm E, Klee P (2009) Modeling intrauterine growth retardation in rodents: impact on pancreas development and glucose homeostasis. Mol Cell Endocrinol 304(1–2):78–83. https://doi.org/10.1016/j.mce.2009.02.019CrossRefPubMed

Simmons RA (2007) Developmental origins of beta-cell failure in type 2 diabetes: the role of epigenetic mechanisms. Pediatr Res 61(5 Pt 2):64R–67R. https://doi.org/10.1203/pdr.0b013e3180457623CrossRefPubMed

Singh RR, Denton KM (2015) Role of the kidney in the fetal programming of adult cardiovascular disease: an update. Curr Opin Pharmacol 21:53–59. https://doi.org/10.1016/j.coph.2014.12.010CrossRefPubMed

Solano ME, Jago C, Pincus MK, Arck PC (2011) Highway to health; or how prenatal factors determine disease risks in the later life of the offspring. J Reprod Immunol 90(1):3–8. https://doi.org/10.1016/j.jri.2011.01.023CrossRefPubMed

Stanner SA, Bulmer K, Andrès C et al (1997) Does malnutrition in utero determine diabetes and coronary heart disease in adulthood? Results from the Leningrad siege study, a cross sectional study. BMJ 315(7119):1342–1348CrossRef

Stelzer IA, Thiele K, Solano ME (2015) Maternal microchimerism: lessons learned from murine models. J Reprod Immunol 108:12–25. https://doi.org/10.1016/j.jri.2014.12.007CrossRefPubMed

Susser E, St Clair D, He L (2008) Latent effects of prenatal malnutrition on adult health: the example of schizophrenia. Ann N Y Acad Sci 1136(1):185–192. https://doi.org/10.1196/annals.1425.024CrossRefPubMed

Tesic D, Hawes JE, Zosky GR, Wyrwoll CS (2015) Vitamin D deficiency in BALB/c mouse pregnancy increases placental transfer of Glucocorticoids. Endocrinology 156(10):3673–3679. https://doi.org/10.1210/en.2015-1377CrossRefPubMed

Thamotharan M, Garg M, Oak S et al (2007) Transgenerational inheritance of the insulin-resistant phenotype in embryo-transferred intrauterine growth-restricted adult female rat offspring. Am J Physiol Endocrinol Metab 292(5):E1270–9. https://doi.org/10.1152/ajpendo.00462.2006CrossRefPubMed

Thornburg KL, Kolahi K, Pierce M, Valent A, Drake R, Louey S (2016) Biological features of placental programming. Placenta 48:S47–S53. https://doi.org/10.1016/j.placenta.2016.10.012CrossRefPubMedPubMedCentral

Tobi EW, Lumey LH, Talens RP et al (2009) DNA methylation differences after exposure to prenatal famine are common and timing- and sex-specific. Hum Mol Genet 18(21):4046–4053. https://doi.org/10.1093/hmg/ddp353CrossRefPubMedPubMedCentral

Urizar GG, Milazzo M, Le H-N, Delucchi K, Sotelo R, Muñoz RF (2004) Impact of stress reduction instructions on stress and cortisol levels during pregnancy. Biol Psychol 67(3):275–282. https://doi.org/10.1016/j.biopsycho.2003.11.001CrossRefPubMed

Veru F, Dancause K, Laplante DP, King S, Luheshi G (2015) Prenatal maternal stress predicts reductions in CD4+ lymphocytes, increases in innate-derived cytokines, and a Th2 shift in adolescents: project ice storm. Physiol Behav 144:137–145. https://doi.org/10.1016/j.physbeh.2015.03.016CrossRefPubMed

Vijayakumar M, Fall CH, Osmond C, Barker DJ (1995) Birth weight, weight at one year, and left ventricular mass in adult life. Br Heart J 73(4):363–367CrossRef

Wallerath T, Witte K, Schäfer SC et al (1999) Down-regulation of the expression of endothelial NO synthase is likely to contribute to glucocorticoid-mediated hypertension. Proc Natl Acad Sci U S A 96(23):13357–13362CrossRef

Watkins AJ, Lucas ES, Wilkins A, Cagampang FRA, Fleming TP (2011) Maternal periconceptional and gestational low protein diet affects mouse offspring growth, cardiovascular and adipose phenotype at 1 year of age. PLoS One 6(12):e28745. https://doi.org/10.1371/journal.pone.0028745CrossRefPubMedPubMedCentral

Weinstock M (2008) The long-term behavioural consequences of prenatal stress. Neurosci Biobehav Rev 32(6):1073–1086. https://doi.org/10.1016/j.neubiorev.2008.03.002CrossRefPubMed

Welberg LA, Seckl JRHM (2000) Inhibition of 11beta-hydroxysteroid dehydrogenase, the foeto-placental barrier to maternal glucocorticoids, permanently programs amygdala GR mRNA e… – PubMed – NCBI. Eur J Neurosci 12(3):1047–1054CrossRef

Werling DM, Parikshak NN, Geschwind DH (2016) Gene expression in human brain implicates sexually dimorphic pathways in autism spectrum disorders. Nat Commun 7:10717. https://doi.org/10.1038/ncomms10717CrossRefPubMedPubMedCentral

Williams SJ, Hemmings DG, Mitchell JM, McMillen IC, Davidge ST (2005) Effects of maternal hypoxia or nutrient restriction during pregnancy on endothelial function in adult male rat offspring. J Physiol 565(1):125–135. https://doi.org/10.1113/jphysiol.2005.084889CrossRefPubMedPubMedCentral

Wing K, Sakaguchi S (2010) Regulatory T cells exert checks and balances on self tolerance and autoimmunity. Nat Immunol 11(1):7–13. https://doi.org/10.1038/ni.1818CrossRefPubMed

Zanardo V, Visentin S, Trevisanuto D, Bertin M, Cavallin F, Cosmi E (2013) Fetal aortic wall thickness: a marker of hypertension in IUGR children? Hypertens Res 36(5):440–443. https://doi.org/10.1038/hr.2012.219CrossRefPubMed

Titel: Fetale Programmierung
verfasst von: Evelyn Annegret Huhn
Anke Diemert
Ekkehard Schleußner
Kurt Hecher
Petra Clara Arck
Verlag: Springer Berlin Heidelberg
Buch: Die Plazenta
Print ISBN: 978-3-662-55621-4

Electronic ISBN: 978-3-662-55622-1

Copyright-Jahr: 2018
DOI: https://doi.org/10.1007/978-3-662-55622-1_13

Springerpflege

Zusammenfassung

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