Skip to main content
Erschienen in: Zeitschrift für Gerontologie und Geriatrie 3/2018

06.04.2017 | Übersichten

Aktuelle Einblicke in die Anämie im Alter

Zusammenfassung zum Symposium „Anämie im Alter“ anlässlich der DGG-Jahrestagung 2016 in Stuttgart

verfasst von: Dr. Gabriele Röhrig, Ines Gütgemann, Gero von Gersdorff, Maria Cristina Polidori, Adrian Lupescu, Florian Lang, Gerald Kolb

Erschienen in: Zeitschrift für Gerontologie und Geriatrie | Ausgabe 3/2018

Einloggen, um Zugang zu erhalten

Zusammenfassung

Anämie im höheren Lebensalter ist ein multifaktorielles Problem, das nach einer interdisziplinären Herangehensweise verlangt. Die Beiträge dieses ersten interdisziplinären Symposiums zu Anämie im höheren Lebensalter umfassten physiologische, histopathologische, nephrologische und neurogeriatrische Aspekte sowie therapeutische Optionen für diese häufige, jedoch noch immer unterdiagnostizierte Erkrankung. Das Symposium war die Auftaktveranstaltung zur Neugründung der Arbeitsgemeinschaft Anämie der Deutschen Gesellschaft für Geriatrie.
Literatur
1.
Zurück zum Zitat Abrahamsen JF, Monsen AL, Landi F, Haugland C, Nilsen RM, Ranhoff AH (2016) Readmission and mortality one year after acute hospitalization in older patients with explained and unexplained anemia – a prospective observational cohort study. BMC Geriatr 16:109CrossRefPubMedPubMedCentral Abrahamsen JF, Monsen AL, Landi F, Haugland C, Nilsen RM, Ranhoff AH (2016) Readmission and mortality one year after acute hospitalization in older patients with explained and unexplained anemia – a prospective observational cohort study. BMC Geriatr 16:109CrossRefPubMedPubMedCentral
2.
Zurück zum Zitat Agüero-Torres H, Winblad B, Fratiglioni L (1999) Epidemiology of vascular dementia: some results despite research limitations. Alzheimer Dis Assoc Disord 13(Suppl 3):S15–S20CrossRefPubMed Agüero-Torres H, Winblad B, Fratiglioni L (1999) Epidemiology of vascular dementia: some results despite research limitations. Alzheimer Dis Assoc Disord 13(Suppl 3):S15–S20CrossRefPubMed
3.
Zurück zum Zitat Bach V, Schruckmayer G, Sam I, Kemmler G, Stauder R (2014) Prevalence and possible causes of anemia in the elderly: a cross-sectional analysis of a large European university hospital cohort. Clin Interv Aging 9:1187–1196PubMedPubMedCentral Bach V, Schruckmayer G, Sam I, Kemmler G, Stauder R (2014) Prevalence and possible causes of anemia in the elderly: a cross-sectional analysis of a large European university hospital cohort. Clin Interv Aging 9:1187–1196PubMedPubMedCentral
4.
Zurück zum Zitat Beutler E, Waalen J (2006) The definition of anemia: what is the lower limit of normal of the blood hemoglobin concentration? Blood 107(5):1747–1750CrossRefPubMedPubMedCentral Beutler E, Waalen J (2006) The definition of anemia: what is the lower limit of normal of the blood hemoglobin concentration? Blood 107(5):1747–1750CrossRefPubMedPubMedCentral
5.
Zurück zum Zitat Boullu-Ciocca S, Darmon P, Sébahoun G, Silaghi A, Dutour-Meyer A (2005) Gelatinous bone marrow transformation in anorexia nervosa. Ann Endocrinol (Paris) 66(1):7–11CrossRef Boullu-Ciocca S, Darmon P, Sébahoun G, Silaghi A, Dutour-Meyer A (2005) Gelatinous bone marrow transformation in anorexia nervosa. Ann Endocrinol (Paris) 66(1):7–11CrossRef
6.
Zurück zum Zitat Chen Y, Qin M, Zheng J, Yan H, Li M, Cui Y, Zhang R, Zhao W, Guo Y (2015) Hemoglobin discriminates stages of chronic kidney disease in elderly patients. Exp Ther Med 10(2):567–571CrossRefPubMedPubMedCentral Chen Y, Qin M, Zheng J, Yan H, Li M, Cui Y, Zhang R, Zhao W, Guo Y (2015) Hemoglobin discriminates stages of chronic kidney disease in elderly patients. Exp Ther Med 10(2):567–571CrossRefPubMedPubMedCentral
7.
Zurück zum Zitat Contreras Mdel M, Formiga F, Ferrer A, Chivite D, Padrós G, Montero A, Grupo Octabaix (2015) Profile and prognosis of patients over 85 years old with anemia living in the community. Octabaix Study. Rev Esp Geriatr Gerontol 50(5):211–215CrossRefPubMed Contreras Mdel M, Formiga F, Ferrer A, Chivite D, Padrós G, Montero A, Grupo Octabaix (2015) Profile and prognosis of patients over 85 years old with anemia living in the community. Octabaix Study. Rev Esp Geriatr Gerontol 50(5):211–215CrossRefPubMed
8.
Zurück zum Zitat Culleton BF, Manns BJ, Zhang J, Tonelli M, Klarenbach S, Hemmelgarn BR (2006) Impact of anemia on hospitalization and mortality in older adults. Blood 107(10):3841–3846CrossRefPubMed Culleton BF, Manns BJ, Zhang J, Tonelli M, Klarenbach S, Hemmelgarn BR (2006) Impact of anemia on hospitalization and mortality in older adults. Blood 107(10):3841–3846CrossRefPubMed
9.
Zurück zum Zitat Di Lullo L, Gorini A, Russo D, Santoboni A, Ronco C (2015) Left ventricular hypertrophy in chronic kidney disease patients: from pathophysiology to treatment. Cardiorenal Med 5(4):254–266CrossRefPubMedPubMedCentral Di Lullo L, Gorini A, Russo D, Santoboni A, Ronco C (2015) Left ventricular hypertrophy in chronic kidney disease patients: from pathophysiology to treatment. Cardiorenal Med 5(4):254–266CrossRefPubMedPubMedCentral
10.
Zurück zum Zitat Franceschi C, Bonafè M, Valensin S, Olivieri F, De Luca M, Ottaviani E, De Benedictis G (2000) Inflamm-aging. An evolutionary perspective on immunosenescence. Ann N Y Acad Sci 908:244–254CrossRefPubMed Franceschi C, Bonafè M, Valensin S, Olivieri F, De Luca M, Ottaviani E, De Benedictis G (2000) Inflamm-aging. An evolutionary perspective on immunosenescence. Ann N Y Acad Sci 908:244–254CrossRefPubMed
12.
Zurück zum Zitat Gomm W, von Holt K, Thomé F, Broich K, Maier W, Fink A, Doblhammer G, Haenisch B (2016) Association of proton pump inhibitors with risk of dementia: a pharmacoepidemiological claims data analysis. JAMA Neurol 73(4):410–416CrossRefPubMed Gomm W, von Holt K, Thomé F, Broich K, Maier W, Fink A, Doblhammer G, Haenisch B (2016) Association of proton pump inhibitors with risk of dementia: a pharmacoepidemiological claims data analysis. JAMA Neurol 73(4):410–416CrossRefPubMed
13.
Zurück zum Zitat Gregory A, Hayflick S (2013) Neurodegeneration with brain iron accumulation disorders overview. Source: GeneReviews® [Internet]. University of Washington, Seattle Gregory A, Hayflick S (2013) Neurodegeneration with brain iron accumulation disorders overview. Source: GeneReviews® [Internet]. University of Washington, Seattle
14.
Zurück zum Zitat Guralnik JM, Eisenstaedt RS, Ferrucci L, Klein HG, Woodman RC (2004) Prevalence of anemia in persons 65 years and older in the United States: evidence for a high rate of unexplained anemia. Blood 104(8):2263–2268CrossRefPubMed Guralnik JM, Eisenstaedt RS, Ferrucci L, Klein HG, Woodman RC (2004) Prevalence of anemia in persons 65 years and older in the United States: evidence for a high rate of unexplained anemia. Blood 104(8):2263–2268CrossRefPubMed
15.
Zurück zum Zitat Hall RK, Haines C, Gorbatkin SM, Schlanger L, Shaban H, Schell JO, Gurley SB, Colón-Emeric CS, Bowling CB (2016) Incorporating geriatric assessment into a nephrology clinic: preliminary data from two models of care. J Am Geriatr Soc 64(10):2154–2158CrossRefPubMedPubMedCentral Hall RK, Haines C, Gorbatkin SM, Schlanger L, Shaban H, Schell JO, Gurley SB, Colón-Emeric CS, Bowling CB (2016) Incorporating geriatric assessment into a nephrology clinic: preliminary data from two models of care. J Am Geriatr Soc 64(10):2154–2158CrossRefPubMedPubMedCentral
16.
Zurück zum Zitat Hamaker ME, Augschoell J, Stauder R (2016) Clinical judgement and geriatric assessment for predicting prognosis and chemotherapy completion in older patients with a hematological malignancy. Leuk Lymphoma 6:1–8 Hamaker ME, Augschoell J, Stauder R (2016) Clinical judgement and geriatric assessment for predicting prognosis and chemotherapy completion in older patients with a hematological malignancy. Leuk Lymphoma 6:1–8
17.
Zurück zum Zitat Hirose K, Hirose M, Tanaka K, Kawahito S, Tamaki T, Oshita S (2014) Perioperative management of severe anorexia nervosa. Br J Anaesth 112(2):246–254CrossRefPubMed Hirose K, Hirose M, Tanaka K, Kawahito S, Tamaki T, Oshita S (2014) Perioperative management of severe anorexia nervosa. Br J Anaesth 112(2):246–254CrossRefPubMed
18.
Zurück zum Zitat Hong CH, Falvey C, Harris TB, Simonsick EM, Satterfield S, Ferrucci L, Metti AL, Patel KV, Yaffe K (2013) Anemia and risk of dementia in older adults: findings from the Health ABC study. Neurology 81(6):528–533CrossRefPubMedPubMedCentral Hong CH, Falvey C, Harris TB, Simonsick EM, Satterfield S, Ferrucci L, Metti AL, Patel KV, Yaffe K (2013) Anemia and risk of dementia in older adults: findings from the Health ABC study. Neurology 81(6):528–533CrossRefPubMedPubMedCentral
19.
Zurück zum Zitat Io H, Aizawa M, Funabiki K, Horikoshi S, Tomino Y (2015) Impact of anaemia treatment for left ventricular remodelling prior to initiation of dialysis in chronic kidney disease patients: Efficacy and stability of long acting erythropoietin stimulating agents. Nephrology (Carlton) 20(Suppl 4):7–13CrossRef Io H, Aizawa M, Funabiki K, Horikoshi S, Tomino Y (2015) Impact of anaemia treatment for left ventricular remodelling prior to initiation of dialysis in chronic kidney disease patients: Efficacy and stability of long acting erythropoietin stimulating agents. Nephrology (Carlton) 20(Suppl 4):7–13CrossRef
20.
Zurück zum Zitat Kawas CH, Kim RC, Sonnen JA, Bullain SS, Trieu T, Corrada MM (2015) Multiple pathologies are common and related to dementia in the oldest-old: The 90+ Study. Neurology 85(6):535–542CrossRefPubMedPubMedCentral Kawas CH, Kim RC, Sonnen JA, Bullain SS, Trieu T, Corrada MM (2015) Multiple pathologies are common and related to dementia in the oldest-old: The 90+ Study. Neurology 85(6):535–542CrossRefPubMedPubMedCentral
23.
Zurück zum Zitat Lattanzio F, Corsonello A, Montesanto A, Abbatecola AM, Lofaro D, Passarino G, Fusco S, Corica F, Pedone C, Maggio M, Volpato S, Incalzi RA (2015) Disentangling the impact of chronic kidney disease, anemia, and mobility limitation on mortality in older patients discharged from hospital. J Gerontol A Biol Sci Med Sci 70(9):1120–1127CrossRefPubMed Lattanzio F, Corsonello A, Montesanto A, Abbatecola AM, Lofaro D, Passarino G, Fusco S, Corica F, Pedone C, Maggio M, Volpato S, Incalzi RA (2015) Disentangling the impact of chronic kidney disease, anemia, and mobility limitation on mortality in older patients discharged from hospital. J Gerontol A Biol Sci Med Sci 70(9):1120–1127CrossRefPubMed
24.
Zurück zum Zitat Leonard AJ, Chalmers KA, Collins CE, Patterson AJ (2014) A study of the effects of latent iron deficiency on measures of cognition: a pilot randomised controlled trial of iron supplementation in young women. Nutrients 6(6):2419–2435CrossRefPubMedPubMedCentral Leonard AJ, Chalmers KA, Collins CE, Patterson AJ (2014) A study of the effects of latent iron deficiency on measures of cognition: a pilot randomised controlled trial of iron supplementation in young women. Nutrients 6(6):2419–2435CrossRefPubMedPubMedCentral
25.
Zurück zum Zitat Liotta G, O’Caoimh R, Gilardi F, Proietti MG, Rocco G, Alvaro R, Scarcella P, Molloy DW, Orlando S, Mancinelli S, Palombi L, Stievano A, Marazzi MC (2016) Assessment of frailty in community-dwelling older adults residents in the Lazio region (Italy): a model to plan regional community-based services. Arch Gerontol Geriatr 68:1–7CrossRefPubMed Liotta G, O’Caoimh R, Gilardi F, Proietti MG, Rocco G, Alvaro R, Scarcella P, Molloy DW, Orlando S, Mancinelli S, Palombi L, Stievano A, Marazzi MC (2016) Assessment of frailty in community-dwelling older adults residents in the Lazio region (Italy): a model to plan regional community-based services. Arch Gerontol Geriatr 68:1–7CrossRefPubMed
26.
Zurück zum Zitat Lobo A, Launer LJ, Fratiglioni L, Andersen K, Di Carlo A, Breteler MM, Copeland JR, Dartigues JF, Jagger C, Martinez-Lage J, Soininen H, Hofman A (2000) Prevalence of dementia and major subtypes in Europe: a collaborative study of population-based cohorts. Neurologic Diseases in the Elderly Research Group. Neurology 54(11 Suppl 5):S4–S9PubMed Lobo A, Launer LJ, Fratiglioni L, Andersen K, Di Carlo A, Breteler MM, Copeland JR, Dartigues JF, Jagger C, Martinez-Lage J, Soininen H, Hofman A (2000) Prevalence of dementia and major subtypes in Europe: a collaborative study of population-based cohorts. Neurologic Diseases in the Elderly Research Group. Neurology 54(11 Suppl 5):S4–S9PubMed
27.
Zurück zum Zitat Lupescu A, Bissinger R, Goebel T, Salker MS, Alzoubi K, Liu G, Chirigiu L, Mack AF, Qadri SM, Lang F (2015) Enhanced suicidal erythrocyte death contributing to anemia in the elderly. Cell Physiol Biochem 36(2):773–783CrossRefPubMed Lupescu A, Bissinger R, Goebel T, Salker MS, Alzoubi K, Liu G, Chirigiu L, Mack AF, Qadri SM, Lang F (2015) Enhanced suicidal erythrocyte death contributing to anemia in the elderly. Cell Physiol Biochem 36(2):773–783CrossRefPubMed
28.
Zurück zum Zitat Nakanishi R, Ishida M, Hodohara K, Yoshida T, Yoshii M, Okuno H, Horinouchi A, Iwai M, Yoshida K, Kagotani A, Okabe H (2013) Prominent gelatinous bone marrow transformation presenting prior to myelodysplastic syndrome: a case report with review of the literature. Int J Clin Exp Pathol 6(8):1677–1682PubMedPubMedCentral Nakanishi R, Ishida M, Hodohara K, Yoshida T, Yoshii M, Okuno H, Horinouchi A, Iwai M, Yoshida K, Kagotani A, Okabe H (2013) Prominent gelatinous bone marrow transformation presenting prior to myelodysplastic syndrome: a case report with review of the literature. Int J Clin Exp Pathol 6(8):1677–1682PubMedPubMedCentral
30.
Zurück zum Zitat Röhrig G, Hörter M, Becker I, Adams A, Gebauer S, Jäger M, Lenzen-Grossimlinghaus R, Modreker MK, Schulz RJ, Willschrei HP, Wirth R (2016) Anemia and hematologic parameters in older patients: results of a German multicentric cross-sectional study. Eur Geriatr Med 7(4):328–332CrossRef Röhrig G, Hörter M, Becker I, Adams A, Gebauer S, Jäger M, Lenzen-Grossimlinghaus R, Modreker MK, Schulz RJ, Willschrei HP, Wirth R (2016) Anemia and hematologic parameters in older patients: results of a German multicentric cross-sectional study. Eur Geriatr Med 7(4):328–332CrossRef
31.
Zurück zum Zitat Röhrig G, Becker I, Schulz RJ, Lenzen-Großimlinghaus R, Willschrei P, Gebauer S, Modreker M, Jäger M, Wirth R (2016) Association between hematologic parameters and functional impairment among geriatric inpatients: Data of a prospective cross-sectional multicenter study („GeriPrävalenz2013“). Maturitas 90:37–41CrossRefPubMed Röhrig G, Becker I, Schulz RJ, Lenzen-Großimlinghaus R, Willschrei P, Gebauer S, Modreker M, Jäger M, Wirth R (2016) Association between hematologic parameters and functional impairment among geriatric inpatients: Data of a prospective cross-sectional multicenter study („GeriPrävalenz2013“). Maturitas 90:37–41CrossRefPubMed
32.
Zurück zum Zitat Romero-Ruperto S, Pérez-Bocanegra MC, Duran-Taberna M, Toscano-Rivera A, Barbé-Gil Ortega J, San José-Laporte A (2015) Anemia in elderly patients admitted to an acute geriatric ward. Rev Esp Geriatr Gerontol 50(3):122–125CrossRefPubMed Romero-Ruperto S, Pérez-Bocanegra MC, Duran-Taberna M, Toscano-Rivera A, Barbé-Gil Ortega J, San José-Laporte A (2015) Anemia in elderly patients admitted to an acute geriatric ward. Rev Esp Geriatr Gerontol 50(3):122–125CrossRefPubMed
33.
Zurück zum Zitat Shikata T, Sasaki N, Ueda M, Kimura T, Itohara K, Sugahara M, Fukui M, Manabe E, Masuyama T, Tsujino T (2015) Use of proton pump inhibitors is associated with anemia in cardiovascular outpatients. Circ J 79(1):193–200CrossRefPubMed Shikata T, Sasaki N, Ueda M, Kimura T, Itohara K, Sugahara M, Fukui M, Manabe E, Masuyama T, Tsujino T (2015) Use of proton pump inhibitors is associated with anemia in cardiovascular outpatients. Circ J 79(1):193–200CrossRefPubMed
34.
Zurück zum Zitat Shultz A, Yam LT (1998) Gelatinous transformation of bone marrow. J Ky Med Assoc 96(1):10–12PubMed Shultz A, Yam LT (1998) Gelatinous transformation of bone marrow. J Ky Med Assoc 96(1):10–12PubMed
35.
Zurück zum Zitat WHO (1968) Nutritional anaemias. Report of a WHO scientific group. World Health Organ Tech Rep Ser 405:5–37 WHO (1968) Nutritional anaemias. Report of a WHO scientific group. World Health Organ Tech Rep Ser 405:5–37
36.
Zurück zum Zitat Wu CY, Hu HY, Chou YJ, Huang N, Chou YC, Li CP (2016) What constitutes normal hemoglobin concentrations in community-dwelling older adults? J Am Geriatr Soc 64(6):1233–1241CrossRefPubMed Wu CY, Hu HY, Chou YJ, Huang N, Chou YC, Li CP (2016) What constitutes normal hemoglobin concentrations in community-dwelling older adults? J Am Geriatr Soc 64(6):1233–1241CrossRefPubMed
37.
Zurück zum Zitat Zumbrennen-Bullough KB, Becker L, Garrett L, Hölter SM, Calzada-Wack J, Mossbrugger I, Quintanilla-Fend L, Racz I, Rathkolb B, Klopstock T, Wurst W, Zimmer A, Wolf E, Fuchs H, Gailus-Durner V, de Angelis MH, Romney SJ, Leibold EA (2014) Abnormal brain iron metabolism in Irp2 deficient mice is associated with mild neurological and behavioral impairments. PLOS ONE 9(6):e98072CrossRefPubMedPubMedCentral Zumbrennen-Bullough KB, Becker L, Garrett L, Hölter SM, Calzada-Wack J, Mossbrugger I, Quintanilla-Fend L, Racz I, Rathkolb B, Klopstock T, Wurst W, Zimmer A, Wolf E, Fuchs H, Gailus-Durner V, de Angelis MH, Romney SJ, Leibold EA (2014) Abnormal brain iron metabolism in Irp2 deficient mice is associated with mild neurological and behavioral impairments. PLOS ONE 9(6):e98072CrossRefPubMedPubMedCentral
Metadaten
Titel
Aktuelle Einblicke in die Anämie im Alter
Zusammenfassung zum Symposium „Anämie im Alter“ anlässlich der DGG-Jahrestagung 2016 in Stuttgart
verfasst von
Dr. Gabriele Röhrig
Ines Gütgemann
Gero von Gersdorff
Maria Cristina Polidori
Adrian Lupescu
Florian Lang
Gerald Kolb
Publikationsdatum
06.04.2017
Verlag
Springer Medizin
Erschienen in
Zeitschrift für Gerontologie und Geriatrie / Ausgabe 3/2018
Print ISSN: 0948-6704
Elektronische ISSN: 1435-1269
DOI
https://doi.org/10.1007/s00391-017-1212-8

Weitere Artikel der Ausgabe 3/2018

Zeitschrift für Gerontologie und Geriatrie 3/2018 Zur Ausgabe

Mitteilungen der DGGG

Mitteilungen der DGGG

Journal Club

Journal Club