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Zeitschrift für Gerontologie und Geriatrie

10.10.2019 | Original Contributions

Administration of alpha-lipoic acid could maintain bone mass and bone strength in senile female rats with alcohol consumption

verfasst von: Junfeng Zhan, Ya Jiang, Nan Zhu, Wang Fang, Gang Wang

Erschienen in: Zeitschrift für Gerontologie und Geriatrie

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Abstract

Previous studies have demonstrated the damaging effect of alcohol (ALH) consumption on bone tissue and bone metabolism. Alpha-lipoic acid (ALA) promotes osteoblast proliferation and inhibits osteoclast proliferation, and positively affects bone regeneration; however, reports about effects of ALA on bone loss for aged female rats with ALH consumption are limited. This study was designed to investigate the impact of treatment with ALA on bone loss for aged female rats with ALH consumption. In this study 30 female Sprague–Dawley rats (22 months old), weighing approximately 520 g, were incorporated. The animals were randomly divided into three groups: group CON, group ALH and group ALH + ALA and received saline, ALH, ALH plus ALA treatment until death at 16 weeks, respectively. The results of maintaining bone mass and bone strength in senile female rats with ALH consumption were evaluated by histology, microcomputerized tomography, gene expression analysis and biomechanical tests. Results from this study indicated that ALH + ALA had stronger effects on the prevention and treatment of osteoporosis in senile female rats with ALH consumption. The ALH + ALA produced stronger effects on the bone volume ratio (BV/TV), trabecular thickness (Tb.Th), trabecular number (Tb.N) and trabecular separation (Tb.Sp), BMD and strength of distal femurs, and regulation of osteogenesis and bone resorption-related gene expression. These results seem to indicate that ALA intervention prevents bone loss in senile female rats with ALH consumption.

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Titel: Administration of alpha-lipoic acid could maintain bone mass and bone strength in senile female rats with alcohol consumption
verfasst von: Junfeng Zhan
Ya Jiang
Nan Zhu
Wang Fang
Gang Wang
Publikationsdatum: 10.10.2019
Verlag: Springer Medizin
Erschienen in: Zeitschrift für Gerontologie und Geriatrie
Print ISSN: 0948-6704
Elektronische ISSN: 1435-1269
DOI: https://doi.org/10.1007/s00391-019-01630-3

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