Abstract
Background: Although Alzheimer’s disease (AD) is a neurodegenerative pathology characterized by accumulation of β-amyloid plaques and neurofibrillary tangles at cerebral level, recent studies highlighted that AD might be the result of many altered physiological processes occurring at whole-organism level. The ability to adapt to stressors by “bending” but not “breaking” can be considered as “resilience”. Individuals incline to withstand such pathophysiological challenges, can be considered more resilient than those that do not. Noticeably, recent literature provide evidence of several exercise-induced positive effects in AD patients including improved brain plasticity, increased adrenal sensitivity, increased vascular health, ameliorations of nitric oxide bioavailability and mitochondrial function. This review explores what resilience means in the AD milieu and the physiological mechanisms by which physical activity may mediate positive adaptative processes that enhance resilience.
Methods: A comprehensive PubMed search was conducted to identify studies about the role of exercise in AD resiliency. The following terminology was applied: Alzheimer resilience, brain resilience, metabolic resilience, cardiovascular resilience, mitochondrial resilience and exercise resilience. Results: Seventy-three studies were included. Five papers defined Alzheimer’s resilience, 15 papers brain resilience, 5 cardiovascular resilience, 1 metabolic resilience, 11 mitochondrial resilience, and 7 exercise resilience. Other twenty-six paper were identified from reference list of authors’ knowledge. Conclusion: Knowing that disturbances in brain, neuroendocrine, vascular and mitochondria metabolism are important events in neurodegeneration and dementia development, the ability of exercise to trigger adaptive mechanisms might represent an important non-pharmacological strategy to improve resilience to AD.Keywords: Alzheimer's disease, exercise, brain resilience, neuroendocrine resilience, cardiovascular resilience, mitochondrial resilience.
Current Alzheimer Research
Title:Resilience to Alzheimer's Disease: The Role of Physical Activity
Volume: 14 Issue: 5
Author(s): Anna Pedrinolla, Federico Schena and Massimo Venturelli
Affiliation:
Keywords: Alzheimer's disease, exercise, brain resilience, neuroendocrine resilience, cardiovascular resilience, mitochondrial resilience.
Abstract: Background: Although Alzheimer’s disease (AD) is a neurodegenerative pathology characterized by accumulation of β-amyloid plaques and neurofibrillary tangles at cerebral level, recent studies highlighted that AD might be the result of many altered physiological processes occurring at whole-organism level. The ability to adapt to stressors by “bending” but not “breaking” can be considered as “resilience”. Individuals incline to withstand such pathophysiological challenges, can be considered more resilient than those that do not. Noticeably, recent literature provide evidence of several exercise-induced positive effects in AD patients including improved brain plasticity, increased adrenal sensitivity, increased vascular health, ameliorations of nitric oxide bioavailability and mitochondrial function. This review explores what resilience means in the AD milieu and the physiological mechanisms by which physical activity may mediate positive adaptative processes that enhance resilience.
Methods: A comprehensive PubMed search was conducted to identify studies about the role of exercise in AD resiliency. The following terminology was applied: Alzheimer resilience, brain resilience, metabolic resilience, cardiovascular resilience, mitochondrial resilience and exercise resilience. Results: Seventy-three studies were included. Five papers defined Alzheimer’s resilience, 15 papers brain resilience, 5 cardiovascular resilience, 1 metabolic resilience, 11 mitochondrial resilience, and 7 exercise resilience. Other twenty-six paper were identified from reference list of authors’ knowledge. Conclusion: Knowing that disturbances in brain, neuroendocrine, vascular and mitochondria metabolism are important events in neurodegeneration and dementia development, the ability of exercise to trigger adaptive mechanisms might represent an important non-pharmacological strategy to improve resilience to AD.Export Options
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Cite this article as:
Pedrinolla Anna, Schena Federico and Venturelli Massimo, Resilience to Alzheimer's Disease: The Role of Physical Activity, Current Alzheimer Research 2017; 14 (5) . https://dx.doi.org/10.2174/1567205014666170111145817
DOI https://dx.doi.org/10.2174/1567205014666170111145817 |
Print ISSN 1567-2050 |
Publisher Name Bentham Science Publisher |
Online ISSN 1875-5828 |
Call for Papers in Thematic Issues
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Aims and Scope: Introduction: Alzheimer's disease (AD) poses a significant global health challenge, with an increasing prevalence that demands concerted efforts to advance our understanding and strategies for prevention, diagnosis, treatment, and rehabilitation. This thematic issue aims to bring together cutting-edge research and innovative approaches from multidisciplinary perspectives to address ...read more
Alzheimer's Disease Drug Development
Alzheimer's disease is a progressive neurodegenerative disorder that affects millions of people worldwide. Despite decades of research, no cure or disease-modifying treatment is available yet. Therefore, the need for developing effective therapies to treat Alzheimer's disease is an urgent matter. This special issue aims to provide a comprehensive overview of ...read more
Current updates on the Role of Neuroinflammation in Neurodegenerative Disorders
Neuroinflammation is an invariable hallmark of chronic and acute neurodegenerative disorders and has long been considered a potential drug target for Alzheimer?s disease (AD) and dementia. Significant evidence of inflammatory processes as a feature of AD is provided by the presence of inflammatory markers in plasma, CSF and postmortem brain ...read more
Deep Learning for Advancing Alzheimer's Disease Research
Alzheimer's disease (AD) poses a significant global health challenge, with an increasing number of individuals affected yearly. Deep learning, a subfield of artificial intelligence, has shown immense potential in various domains, including healthcare. This thematic issue of Current Alzheimer Research explores the application of deep learning techniques in advancing our ...read more
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